Platelet Rich Plasma is an advanced regenerative medicine therapy that utilizes the body’s own natural healing mechanisms to heal injured soft tissue, including tendons, muscles, and ligaments. Platelet Rich Plasma (PRP) is produced from the patient’s own blood by taking a blood sample (the same as having your blood drawn at the lab) and then processing that sample in a centrifuge. This processing allows us to extract a small amount of plasma with a very high concentration of platelets – this is the Platelet Rich Plasma (PRP). The Platelet Rich Plasma (PRP) is then injected into the injured area to help promote healing.
Platelet Rich Plasma (PRP) works several ways. First, Platelet Rich Plasma (PRP) initiates wound repair by releasing specialized growth factors to activate and amplify the body’s natural healing mechanisms. Second, Platelet Rich Plasma (PRP) suppresses cytokine release and limits localized inflammation, which allows for improved tissue healing and regeneration. Finally, Platelet Rich Plasma (PRP) produces specialized signaling proteins that attract white blood cells (WBCs), enhancing the body’s ability to fight localized infections.
Platelet Rich Plasma (PRP) therapy is a minor injection procedure that is typically performed in our office at Capitol Pain Institute. Patients should not use any corticosteroid medications for 2-3 weeks or nonsteroidal anti-inflammatory drugs (NSAIDs) for at least 1 week prior to the procedure. It is recommended that patients increase their fluid intake for 24-48 hours prior to Platelet Rich Plasma (PRP) therapy.
The first step in Platelet Rich Plasma (PRP) therapy is to draw the blood sample.  This is done in the pre-procedure room using a butterfly (no different than going to the lab and having your blood drawn for lab tests).  Once this is complete, the blood is put into a specialized container and placed in the centrifuge for processing.  It takes about 15 minutes for the processing to be completed.

During the processing time, you will be taken to the procedure room.  If your have requested IV sedation for the procedure, then we will start your IV during this time.  The area to be injected will be cleaned with an antiseptic solution and a sterile drape will be placed over this area to keep it clean for the procedure. A local anesthetic will then be injected into your skin to make it numb.  After this, either ultrasound or fluoroscopy (live X-ray) will be used to guide the injection needle to the proper injection site.  The Platelet Rich Plasma (PRP) will then be injected into the site and the needle will be removed.

Most patients experience soreness after the procedure that lasts from 1-10 days. The soreness is a result of the healing cascade beginning and it is actually a good thing – it means that the Platelet Rich Plasma (PRP) is starting to work. Most patients start to feel relief from the Platelet Rich Plasma (PRP) about 2-4 weeks after the procedure.
The first 24 hours after Platelet Rich Plasma (PRP) is critical for allowing the Platelet Rich Plasma (PRP) to begin working. Therefore, at Capitol Pain Institute, we recommend extremely limited activity for the first 24 hours after injection and then light activity for the 1st week following Platelet Rich Plasma (PRP) therapy. After the 1st week, patients may slowly increase their activity back to normal levels.
The vast majority of patients do not require sedation for the Platelet Rich Plasma (PRP) therapy, however, we will provide light sedation for the procedure at your request. Patients who are receiving sedation must have a responsible adult with them to drive them home.
Most patients prefer to have a family member or friend drive them for their Platelet Rich Plasma (PRP) therapy, however, you may drive yourself to the procedure as long as you are not requesting sedation.